Creatine has many actions likely to benefit the fetus and newborn, because pregnancy is a state of heightened metabolic activity, and the placenta is a key source of free radicals of oxygen and nitrogen.

  • Brief

    Summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy.

  • Background

    While the use of creatine in human pregnancy is yet to be fully evaluated, its long-term use in healthy adults appears to be safe, and its well documented neuroprotective properties have recently been extended by demonstrations that creatine improves cognitive function in normal and elderly people, and motor skills in sleep-deprived subjects.

  • Key takeaways

    The use of creatine in human pregnancy and neonatal practice should be evaluated as a possible prophylactic therapy in its own right, or as an adjunct to conventional treatments such as magnesium sulphate when preterm labour is likely, or in HIE when hypothermia is used.

  • Key contributors

    Dr Hayley Dickinson

  • Full report

    Read the full report here.

  • Funding amount